Publications

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  1. Hu P, Rychik J, Zhao J, Bai H, Bauer A, Yu W, Rand EB, Dodds KM, Goldberg DJ, Tan K, Wilkins BJ, Pei L. Single-cell multiomics guided mechanistic understanding of Fontan-associated liver disease. Sci Transl Med. 2024 Apr 24;16(744):eadk6213. doi: 10.1126/scitranslmed.adk6213. Epub 2024 Apr 24. PMID: 38657025. (Click here to read the page)
  2. Gan L, Pei L. Epigenetic Regulation of Heart-ECHS∗ . J Am Coll Cardiol Basic Trans Science. 2022 Apr, 7 (4) 363–365.
  3. Zhao J, Pei L. Cardiac Endocrinology: Heart-Derived Hormones in Physiology and Disease. J Am Coll Cardiol Basic Trans Science. 2020 Sep, 5 (9) 949–960.
  4. Hu P, Liu J, Zhao J, Wilkins BJ, Lupino K, Wu H, Pei L. Erratum: Single-nucleus transcriptomic survey of cell diversity and functional maturation in postnatal mammalian hearts. Genes Dev. 2019 Nov 1;33(21-22):16131. 
  5. Zhao J, Lupino K, Pei L. Single Cell Analysis of Postnatal Heart Development and Disease. Circulation Research. 2019 Oct, 16 (125) A281.
  6. Hu P, Liu J, Zhao J, Wilkins BJ, Lupino K, Wu H, Pei L: Single-nucleus transcriptomic survey of cell diversity and functional remodeling in the postnatal developing hearts. Genes & Development 32(19-20): 1344-57, Oct 2018.
  7. Zhao J, Lupino K, Wilkins BJ, Qiu C, Liu J, Omura Y, Allred AL, McDonald C, Susztak K, Barish GD, Pei L: Genomic integration of ERRγ-HNF1β regulates renal bioenergetics and prevents chronic kidney disease. Proc Natl Acad Sci USA 115(21): E4910-E4919, May 2018.
  8. Li J, Liu J, Lupino K, Liu X, Zhang L, Pei L: GDF15 maturation requires proteolytic cleavage by PCSK3, 5 and 6. Molecular and Cellular Biology 38(21): e00249-18, Oct 2018 Notes: DOI 10.1128/MCB.00249-18.
  9. Pei L, Wallace DC : Mitochondrial Etiology of Neuropsychiatric Disorders. Biological Psychiatry 83(9): 722-730, May 2018.
  10. Wang T, Liu J, McDonald C, Lupino K, Zhai X, Wilkins BJ, Hakonarson H, Pei L : GDF15 is a heart-derived hormone that regulates body growth. EMBO Molecular Medicine 9: 1150-1164, 2017.
  11. Wang T, McDonald C, Petrenko NB, Leblanc M, Giguere V, Evans RM, Patel VV, and Pei L: ERRalpha and ERRgamma are essential coordinators of cardiac metabolism and function. Mol Cell Biol. 35(7): 1281-1298, 2015.
  12. Pei L, Mu Y, Leblanc M, Alaynick W, Barish GD, Pankratz M, Tseng TW, Kaufman S, Liddle C, Yu RT, Downes M, Pfaff SL, Auwerx J, Gage FH, Evans RM: Dependence of hippocampal function on ERRγ regulated mitochondrial metabolism. Cell Metab 21(4): 628-636, 2015.
  13. Pei L, Leblanc M, Barish G, Atkins A, Nofsinger R, Whyte J, Gold D, He M, Kawamura K, Li H-R, Downes M, Yu R, Powell HC, Lingrel JB, Evans RM: Thyroid hormone receptor repression is linked to type I pneumocyte associated respiratory distress syndrome. Nat Med 17(11): 1466-1472, 2011.
  14. Pei L, and Evans RM: Retrofitting fat metabolism. Cell Metab 9(6): 483-484, 2009.
  15. Pei L, Waki H, Vaitheesvaran B, Wilpitz DC, Kurland IJ, and Tontonoz P: NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism. Nat Med 12(9): 1048-1055, 2006.
  16. Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P: Induction of NR4A Orphan Nuclear Receptor Expression in Macrophages in Response to Inflammatory Stimuli. J Biol Chem 280(32): 29256-29262, 2005.
  17. Pei L, Castrillo A, and Tontonoz P: Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77. Mol Endocrinol 20(4): 786-794, 2006.